It is not possible to give a definitive answer as to whether the effects of stress are reversible.
The hippocampus is one of the areas of the brain that is most affected by stress. Fortunately, it is also an area of the brain where it is possible to regenerate new brain cells.
On one hand, we know that long-term exposure to stress does kill off cells in the hippocampus and harms its performance. This can lead to significant memory problems.
It is also well-established that chronic exposure to stress is associated with significantly higher risk of developing dementia.
On the other hand, various studies including the observation of animals have demonstrated that the brain can recover from stress.
These studies suggest that several factors seem to have a restorative effect on brain function and memory. The first is eliminating or massively reducing chronic stress. At the same time, it’s important to give the brain and body time to:
How completely the brain can recover, and how long it would take, we are not able to say. But it is worth the effort to do these things because of the known damage that chronic stress can cause.